![]() Recently, a new formula for calculation of LDL-C has been proposed by Anandaraja et al., The calculation of LDL-C proposed by Anandaraja et al., (AR-LDL-C) is AR-LDL-C = 0.9 TC- (0.9 TG/5)-28. The use of this formula is also not recommended for Type II diabetes mellitus, nephrotic syndrome and chronic alcoholic patients, because, in these conditions too, the triglyceride to cholesterol ratio in VLDL is altered. Consequently, if a non-fasting sample is used for F-LDL-C, there would be an overestimation of VLDL-C and underestimation of LDL-C. ![]() This ratio is altered in non-fasting samples (containing chylomicrons and chylomicron remnants). A fasting sample is mandatory for F-LDL-C because the Friedewald formula assumes that the triglyceride to cholesterol ratio in Very Low Density Lipoprotein (VLDL) is constant. The National Cholesterol Education Programme (NCEP) Adult Treatment Panel III (ATP III) recommends a goal of maintaining serum LDL-C concentration 400 mg/dl or < 100mg/dL or in patients with type III or type I hyperlipoproteinaemia. Elevated serum Low-Density Lipoprotein Cholesterol (LDL-C) concentration is a well-known atherogenic risk factor with a high predictive value for coronary heart disease.
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